All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-Dihydroxyvitamin D3 in normal human keratinocytes

1998 ◽  
Vol 174 (1) ◽  
pp. 1-8 ◽  
Author(s):  
David F. C. Gibson ◽  
Daniel D. Bikle ◽  
Jonathan Harris
Keyword(s):  
Retinoic Acid ◽  
Human Keratinocytes ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Normal Human Keratinocytes ◽  
Normal Human

Regulation of the BCL-2 family members and betal integrin by cultured normal human keratinocytes treated with all-trans-retinoic acid (ATRA)

1999 ◽  
Vol 91 (7) ◽  
pp. 560-560
Author(s):  
Rachida Nachat ◽  
Stéphane Sermadiras ◽  
Marc Dumas ◽  
Frédéric Bonté ◽  
Marie-Hélène Ratinaud
Keyword(s):  
Retinoic Acid ◽  
Family Members ◽  
Human Keratinocytes ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Normal Human Keratinocytes ◽  
Normal Human

Differential Effects of All-Trans Retinoic Acid on the Growth of Human Keratinocytes and Mouth Carcinoma Epidermoid Cultures. Involvement of GRIM-19 and Complex I of the Respiratory Chain

2007 ◽  
Vol 20 (4) ◽  
pp. 719-729 ◽  
Author(s):  
F. Papa ◽  
M. Delia ◽  
R. Trentadue ◽  
D. Panelli ◽  
F. Bellomo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Growth ◽  
Respiratory Chain ◽  
Complex I ◽  
Human Keratinocytes ◽  
Mitochondrial Respiratory Chain ◽  
Oxidoreductase Activity ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Normal Human

Squamous cell carcinoma (SSC) is the most frequent malignant tumor of the oral cavity. A study on the effect of all-trans retinoic acid (RA) on cell growth, expression of GRIM-19 and content and activity of complex I of the mitochondrial respiratory chain in normal human keratinocytes (NHEK) and mouth carcinoma cells with low (HN) and high (KB) transformation grade was carried out. In NHEK cells, RA treatment resulted in growth suppression, significant overexpression of GRIM-19 protein, enhanced content of complex I but depressed activity of NADH-UQ oxidoreductase activity of the complex. In HN cells, RA treatment depressed cell growth, inhibited the enzymatic activity of complex I but had no significant effect on the levels of GRIM-19 and complex I. In KB cells RA had no effect on cell growth, GRIM-19 expression, content and activity of complex I.

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